Trabalho de Conclusão de Residência em área profissional da saúde em medicina veterinária, com ênfase em patologia clínica veterinária: relação Gama-glutamil transferase: creatinina urinária no diagnóstico de patologias renais em caninos

Abstract

This study aimed to evaluate or use the urinary gamma-glutamyl transferase: creatinine (GGT: CRT) ratio as a marker of renal pathologies, as well as to analyze the possible effects on frozen analyzes. Thirty-six dog urine tablets were used, which were admitted to the Veterinary Clinical Pathology Laboratory of the Veterinary Medicine Department of the Veterinary Hospital of the Federal Rural University of Pernambuco. The samples were classified into three stages: no renal or sadistic disease (S) and sick (D), recorded by Group I, composed of those samples analyzed within four hours and Group II as the samples. frozen at -20 ° for up to eight days. In group I, stage S patients with mean GGT: CRT were 0.56 (+- 0.21), in D stage, mean GGT: CRT values were 2.27 (+- 0.91). In group II, the GGT: CRT ratio values were lower than those observed in group I at all stages of the disease. It is noteworthy that the difference in the variation of the D parameters when the patients in group S were 1.41 times higher. It concluded that the GGT: urinary CRT ratio is a good marker for evaluation of active kidney injury in dogs. As for the conservation of the samples, as analyzes of the urine samples, performed up to four hours after the sample collection, good sensitivities of diagnostic evaluation and freezing were detected.