Desenvolvimento de um protótipo antitumoral à base de boro-10 a ser aplicado na terapia de captura de nêutrons

Abstract

In order to develop new prototypes capable of acting as neutron captors, this work presents the synthesis of a system based on polyvinyl alcohol and boric acid for future applications in neutron capture therapy and their characterizations carried out by thermogravimetric analysis, differential scanning of calorimetry, infrared spectroscopy and nuclear magnetic resonance of 1H, 13C and 11B. Two compounds were obtained, reproducible with the proposed methodology, with distinct physical and chemical characteristics, with a pH between 6.6 - 6.8. Thermal analysis data (TGA and DSC) corroborate to confirm the connections made between Boron and the polymer matrix. Boron-11 nuclear magnetic resonance data confirm the formation of three different species of boron, already described in the literature. The performance of the acute toxicity test via the OECD-423 protocol classifies the compound in category 4, showing good agreement for its future application in therapy.