Monitoramento tecnológico de nanoemulsões produzidas a partir de óleos essenciais e sua aplicação na saúde humana e veterinária

Abstract

Nanoemulsions produced with essential oils (NEOEs) are formulations with great therapeutic potential within human and veterinary health, and can be applied for the most diverse purposes. The present work aimed at technological monitoring, raising patents and articles referring to NEOEs with applicability in the field of human and veterinary health. The documents were obtained through a systematic review, in several databases and went through inclusion and exclusion criteria, and then were grouped for the analysis of variables, such as: Type of documents by country; Publication timeline by type of document; Application area; Applicability of NEOEs; among others. 153 articles and 34 patents were found. It was observed that Brazil is the country with the highest number of publications for both types of documents. For articles, along with Brazil, we observe that India and Iran have a large amount of publication, but they have a low amount of patent publication. This indicates that these countries are not protecting their products, reducing the inventive potential of their respective nations. When we evaluate patents, Brazil remains in first place, but now alongside it, we have China and the United States, that is, these last two countries protect their ideas more than they publish scientific articles. Analyzing the applicability of NEOEs, there is a greater exploration of their cytotoxic potential, that is, being applied to the destruction of pathogenic cells (Bacteria, fungi, protozoa, worms and cancer cells). Most of the patents found belonged to educational institutions, and few to private industry. In the world, little attention has been given to the development of NEOE with application in veterinary medicine, which makes it an unexplored field, but with great potential as it is a high monetary power industry. Although there is a greater amount of products aimed at human health, few systemic diseases have been explored for the application of NEOEs, which would be another promising field for the development of future research.