Componentes orgânicos voláteis (COV) como biomarcadores da COVID-19

Abstract

In March 2020, the World Health Organization (WHO) declared the COVID-19 pandemic when the world had already reported 118,000 cases, 4.2 thousand deaths, and 114 countries with confirmed cases. With the lack of effective treatments and vaccines, scientists turned their attention to diagnosing the disease and finding ways to prevent its transmission. Although RT-PCR testing is widely used, it has some disadvantages, such as invasiveness of sample collection, cost, and time. Detection of volatile organic compounds (VOC) has emerged as a less invasive and effective alternative for COVID-19 diagnosis. Infection by a pathogenic agent can trigger a series of changes in the organism's cellular behavior. Understanding the molecules involved in this process is critical for developing diagnostic techniques that can help combat the pandemic. To investigate the relationship between COVID-19 and organic volatile biomarkers (VOC), a systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.