Aplicações de reações multicomponentes em química medicinal

Abstract

The Multicomponent Reactions (RMCs) are very important reactions in the field of organic chemistry and have been expanding over the decades. These reactions start from 3 or more components to form a single product, in a method known as one-pot, that is, in a single container. Which brings many advantages due to meet the Green Chemistry principles, for being a linear and rapid synthesis, and still collaborate for the call “atomic economy”; in addition to forming complex molecules starting from simple and accessible precursors, as a basis for the formation of intermediaries or products with biological activities, thus bringing great collaborations and applications in Medicinal Chemistry. Many reactions are based on the principle of RMCs, among the best known and widely used are the reaction of Strecker, Hantzsch, Biginelli, Mannich, Passerini and Ugi, the last two being based on isocyanides.