Síntese para obtenção do 3,7-dimetóxikaempferol visando à atividade leishmanicida

Abstract

Flavonoids are a class of substance widely distributed in the plant kingdom and are found in stems, fruits, flowers etc. Numerous studies have been carried out to deepen the knowledge of the biological activity of flavonoids, some of which have been reported as antimicrobial, anti-inflammatory and antiviral activities. The present work aims to characterize methoxylated and benzylated derivatives of naringenin (9) in addition to testing protective reactions for future prototypes of leishmanicidal drugs, through changes in flavonoids. In this work, (9) was used as starting material for future reactions one of which being the methylation reaction regioselective to obtain 7-methoxy-naringenin, using dimethyl sulfate and potassium carbonate in acetone at room temperature, yielding 72%, and then the product formed is subjected to a protection reaction using benzyl bromide, however under the conditions tested the opening of ring C occurred , it was necessary to test other means of protection using silicon reagents and cyclization alternatives in an attempt to supply the desired products. The products were characterized by the usual methods in the literature and available in the research group, such as NMR, infrared and melting point.