Cisplatina: uma revisão de literatura

Abstract

Cisplatin has been the subject of several studies since its discovery in the 1960s and used as a standard compound in evaluations of the effectiveness of platinum-based chemotherapy treatments. Analyzing the mechanisms of intracellular action of cisplatin, as well as the resistance mechanisms associated with it, is of fundamental importance, since many analogous com-pounds were and are elaborated until today in order to find less adverse effects and resistance to treatment, as well as greater specificity to tumor cells and more effective intracellular toxicity. For this, it is necessary to have knowledge about cisplatin, since its mechanisms of action on DNA is a pattern observed in this compound and its analogues from later generations. With these points in mind, this monograph aimed to identify some of the important productions on cisplatin in the last 5 years through a literature review. The methodology applied for the review consists of a series of steps ranging from the choice of topic to the final writing of the review, being extremely important for a good organization, selection, analysis, interpretation, writing. In all, 46 productions were chosen for a critical analysis. Topics were separated for the interpretation of the results of the analysis of the texts on cisplatin, namely: mechanism of action, adverse effects and new technologies. The 48 productions were organized and separated into topics according to the similar perspectives between the authors and a critical summary and interpretation of these works was performed. As final considerations, the review highlighted the importance of gathering such texts on cisplatin for study and instructions on the directions and trends of new technologies, such as the use of nanoemulsions and nanocarriers for cisplatin with the objective of increasing the efficiency of chemotherapy based on this compound and reduce the side effects associated with it.