Síntese de 2-aminoalquil-3-alquenil-1,4-naftoquinona funcionalizadas como matérias-primas na obtenção de novas moléculas bioativas

Abstract

Quinones represent a large and varied family of metabolites of natural distribution. The interest in these substances has been intensified in recent years due to their pharmacological importance. The main interest in quinones comes from their capacity to induce oxidative stress in cells. This stress can also result from the action of many toxic environmental agents on living beings, such as gamma and ultraviolet radiation, ozone, and automobile pollutants in the air, as well as from certain substances in the food chain and from smoking. Natural and synthetic, quinones are substances known to possess potent and varied types of biological activities such as antitumor, molluscicidal, leishmanicidal, anti-inflammatory, antifungal, trypanocidal, antiprotozoal and inhibitors of the reverse transcriptase enzyme of the HIV-1 virus. The present work aims to establish a relationship between natural quinones and, by means of organic synthesis, obtain organic derivatives that possess biological activity.